Mutations in PDE6D impair the function of its cognate protein, phosphodiesterase 6D (PDE6D), in prenylated protein trafficking towards the ciliary membrane, causing the human ciliopathy Joubert Syndrome (JBTS22) and retinal degeneration in mice.In this study, we purified the prenylated cargo of PDE6D by affinity proteomics to gain insight into PDE6
Date palm tree (DPT) and pine tree (PT) needles in forests form a combustible mat, posing fire risks during summer in Pakistan that damage vegetation, wildlife habitats, and biodiversity and impact local livelihoods.In this article, sintered ceramic specimens were prepared at different weight concentrations (DPT5, DPT10, DPT20, and DPT 30 and PT5,
O aleitamento materno exclusivo nos primeiros seis meses de vida é essencial para o crescimento adequado da criança, além de garantir a imunidade e evitar morbidades futuras.Passado esse período, é indicado iniciar alimentação complementar, de forma gradual e com uso de dieta equilibrada e variada.O texto objetiva investigar as recomendaçõ
Mutations in the nuclear encoded subunits of mitochondrial complex I (NADH:ubiquinone oxidoreductase) may cause circumscribed cerebral lesions ranging from degeneration of the striatal and brainstem gray matter (Leigh syndrome) to leukodystrophy.We hypothesized that such pattern of regional pathology might be due to local differences in the depende